It basically depends what can kind of game it is apk tool can help you mod mostly games which are text based or java games
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While for modding unity games you can use net reflector, dnspy or unity editor
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Then the last one is whether the game uses .libfiles in its resource or asset folder then you will have to use IDA hacking which by far the most difficult one
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If you want to know in detail about each method than you can check the tutorial in the android modding university hope it helps